Catechol-O-methyltransferase and breast cancer risk
نویسندگان
چکیده
منابع مشابه
Polymorphic catechol-O-methyltransferase gene and breast cancer risk.
We examined 483 Finnish breast cancer cases and 482 population controls to determine the potential effect of catechol-O-methyltransferase (COMT) genotype in individual susceptibility to breast cancer. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression after adjustment for known or suspected risk factors for breast cancer. When studied separa...
متن کاملCatechol-O-methyltransferase gene polymorphism and post-menopausal breast cancer risk.
Estrogen is involved in breast carcinogenesis. Hypotheses have been raised that its effect is modified by enzymes such as catechol-O-methyltransferase (COMT) that deactivate potentially genotoxic estrogen metabolites. We have investigated the association between the functional genetic Val108/158Met polymorphism in COMT and breast cancer risk in a large population-based case-control study perfor...
متن کاملGenetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk.
Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of estrogen catechols. In a case-control study, we evaluated the association of the low-activity allele (COMT(Met)) with breast cancer risk. Compared to women with COMT(Val/Val), COMT(Met/Met) was associated with an increased risk among premenopausal women [odds ratio (OR), 2.1; confidence interval (CI), 1.4-4.3] but wa...
متن کاملComprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer risk.
Because catechol-O-methyltransferase (COMT) catalyzes the addition of methyl groups to stabilize catechol estrogens that may induce DNA damage, genetic variants could influence breast cancer risk. To comprehensively characterize genetic variation in this gene, we selected haplotype-tagging single nucleotide polymorphisms (htSNP) in COMT. A total of 11 htSNPs (including COMT Val(158)Met) were se...
متن کاملBreast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms.
Catechol O-methyltransferase (COMT)-catalyzed methylation of catecholestrogens has been proposed to play a protective role in estrogen-induced genotoxic carcinogenesis. We have taken a comprehensive approach to test the hypothesis that genetic variation in COMT might influence breast cancer risk. Fifteen COMT single nucleotide polymorphisms (SNPs) selected on the basis of in-depth resequencing ...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1998
ISSN: 1460-2180
DOI: 10.1093/carcin/19.11.1943